Sildalist Strong 140 mg is a combination medication that contains two active ingredients: sildenafil citrate (100 mg) and tadalafil (40 mg). Sildenafil citrate is a medication primarily used to treat erectile dysfunction (ED) in men. It works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which leads to increased levels of cyclic guanosine monophosphate (cGMP) in smooth muscle cells. This results in relaxation of the smooth muscles and dilation of blood vessels, allowing for increased blood flow to the penis during sexual stimulation, which helps men achieve and maintain an erection. Tadalafil is also a medication used to treat erectile dysfunction (ED) in men. It works in a similar way to sildenafil citrate by inhibiting PDE5 and increasing cGMP levels in smooth muscle cells, leading to improved blood flow to the penis and enhanced erectile function. Tadalafil is known for its longer duration of action compared to sildenafil, with effects lasting up to 36 hours.