Malegra DXT contains sildenafil citrate, a phosphodiesterase type 5 (PDE5) inhibitor. Sildenafil helps improve blood flow to the penis, aiding in achieving and maintaining erections during sexual stimulation. This makes Malegra DXT effective in treating ED. Malegra DXT also contains duloxetine, a selective serotonin and norepinephrine reuptake inhibitor (SNRI). Duloxetine helps delay ejaculation, thereby addressing premature ejaculation, which is characterized by uncontrollable ejaculation either before or shortly after sexual penetration.