Sildenafil Citrate in Cenforce 50 mg works by inhibiting the enzyme PDE5 (phosphodiesterase type 5), which normally breaks down cyclic GMP (cGMP) in the penis. cGMP is a molecule that helps relax the smooth muscles of the penis and increases blood flow, which is essential for achieving and maintaining an erection during sexual stimulation. By preventing PDE5 from breaking down cGMP, Cenforce 50 mg helps enhance blood flow, facilitating an erection when sexually aroused.